刺五加总苷提取及纯化工艺研究进展 |
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刺五加总苷提取及纯化工艺研究进展 Acanthopanax Aggregation Nucleoside extraction and purification process research progress 发布时间：2011-08-01 浏览量：63 收藏数：0 评论数：0 总览 评价 张博1， 郭冷秋2* （ 1、黑龙江中医药大学研究生学院； 2、黑龙江中医药大学药学院，哈尔滨 150040； ）
摘要： 刺五加总苷是刺五加中主要活性成分之一，具有确切的抗疲劳、抑制肿瘤的生长及减轻抗癌药物的毒性、减少肿瘤手术后并发症的发生率及降低死亡率等作用。本文通过对近20多年国内外刺五加总苷提取和纯化方面的相关文献进行了系统的整理，总结了刺五加中有效成分的提取方法主要有水提、甲醇提、乙醇加热回流提取和超临界二氧化碳提取等，纯化方法目前使用最为广泛的是大孔吸附树脂法。本论文综述了刺五加总苷提取和纯化工艺的研究进展，为刺五加总苷进一步的纯化研究及新药开发奠定了一定的基础。
关键词： 刺五加总苷；提取；纯化 ZHANG Bo1， GUO Lengqiu2* （ 1、The Graduate School,HeiLongJiang University Of Chinese Medicine； 2、Pharmaceutical Shool,HeiLongJiang University Of Chinesee Medicine 150040； ）
Abstract： Acanthopanax senticosus glycosides is one of the main active ingredient,it has a definite anti-fatigue, inhibition of tumor growth and reduce the toxicity of anticancer drugs to reduce tumor incidence of postoperative complications and mortality and so on.Through the nearly 20 years research at home and abroad, Acanthopanax Aggregation Nucleoside extraction and purification of relevant literature was summarized in this paper. We summarizes the extraction methods of active ingredients in Acanthopanax including water extraction, methanol extraction, heat reflux extraction of ethanol, supercritical carbon dioxide extraction and purification methods are currently the most widely used macroporous resin.In this paper the Acanthopanax aggregation nucleoside extraction and purification process research progress was reviewed systematically.It lays foundation for the purification of the acanthopanax aggregation nucleoside and new drug development.
Keywords： Acanthopanax aggregation nucleoside; extraction; purification
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