golgi apparatus localization of znt7 in the mouse cerebellum |
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golgi apparatus localization of znt7 in the mouse cerebellum 收藏此文
全部作者 ： 高慧玲 王辛 池志宏 黄立平 王占友
第一作者单位 ： 中国医科大学组胚教研室
论文摘要 ： the cerebellum contains a significant amount of zinc ions. however, little is known about zinc homeostasis in the cerebellum. we have recently reported that four members of the zinc transporter (znt) family, znt1, znt3, znt4, and znt6, are abundantly expressed in the mouse cerebellum. in the present study, we reported that znt7 was present throughout the cerebellar cortex. znt7 immunoreactivity was predominately present in the somas and primary dendrites of the purkinje cells. znt7 was also present in the bergmann glial cell bodies as well as their radial processes, which extended into the molecular cell layer. confocal immunofluorescence results demonstrated that the expression of znt7 overlapped with that of tgn38 in the somas of the purkinje cells and granule cells. immuno-electron microscopic study showed that znt7 was localized to the membrane of the golgi apparatus in the somas of the purkinje cells, bergmann glial cells, and granule cells. western blot analysis demonstrated that a considerable amount of znt7 was expressed in the cerebellum compared to the hippocampus. in addition, zinc autometallographic staining revealed that chelatable zinc was predominately distributed in the bergmann glial cell bodies and their radial processes. these findings suggest a significant role of znt7 in zinc homeostasis in the mouse cerebellum.
关键词 ： zinc transporter; cerebellum; purkinje cells; bergmann cell; mouse
发表日期 ： 2007年12月30日
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